Sommario
This position is located in Cambridge, MA.
The Pharmacokinetic Sciences (PKS) Department within the Novartis Biomedical Research Division (BR) in Cambridge, Massachusetts is looking for a laboratory-based biotransformation scientist with experience in metabolite identification and profiling to join their global biotransformation team with groups in Europe and North America.
As a biotransformation scientist, you will develop state-of-the-art analytical methodologies using ultra/high performance liquid chromatography (U/HPLC) coupled with high resolution mass spectrometry (HRMS) to identify metabolites and elucidate biotransformation pathways from complex biologic matrices. This role will require you to be familiar with various in vitro enzymatic systems used in drug metabolism biotransformation studies as well as extraction procedures such as protein precipitation, liquid/liquid extraction (LLE), and solid phase extraction (SPE). In addition, you will be familiar with mass spectrometry fragmentation interpretation, structural elucidation, and data processing requirements needed to characterize metabolites of small molecules. Experience with the biotransformation of peptides, oligonucleotides, and/or intact proteins would be considered highly advantageous.
About the Role
As the successful candidate you will plan and execute fit-for-purpose experiments, maintain the laboratory environment/instruments, and support the development of new technologies. You will also be expected to interact with and present your findings in team meetings, document your findings in an electronic notebook, and prepare internal reports. Furthermore, depending on the seniority of the successful candidate, you will represent the ADME line function in PKS sub-teams and project teams, collaborate in the preparation of external publications, and contribute to registration documents.
Key Responsibilities:
· Design and execution of biotransformation studies to assess metabolic pathways and structural elucidation of metabolites
· Organize and prepare experimental protocols and study reports with upload of results to a centralized database
· Presentation of key findings to team members and/or other stakeholders
· Support in vitro and in vivo discovery, pre-clinical, and clinical development biotransformation studies
· Assure quality standard guidelines and safe work practices are applied while working in the laboratories
Essential Requirements:
- Degree in Analytical/Medicinal Chemistry, Biochemistry, Biology, or Pharmaceutical Sciences, with knowledge of drug discovery/development
- PhD with 0 years, MS with 3+ years, or BS with 8+ years of relevant experience
- Applicants with additional research/industrial experience relevant to drug metabolism or mass spectrometry may be considered at the Principal Scientist I level
- Hands-on experience in operation, maintenance, and troubleshooting of state-of-the-art high resolution mass spectrometers
- Excellent oral and written communication skills
- Careful attention to detail, exceptional organizational skills, and ability to multitask
- Team player with ability to be flexible and adapt to a changing environment
Desirable requirements:
- Prior experience with small molecule metabolite identification, structural elucidation, and biotransformation studies
- Familiarity with in vitro systems commonly used for drug metabolism studies (hepatocytes, homogenate, microsomes, S9 fraction, recombinant enzymes)
- Experience with intact protein, immunoprecipitation, peptide, and/or oligonucleotide analysis would be considered a bonus
This is a dual level posting. The final level and title of the offer role would be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level the role has been offered.
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Benefits and Rewards:
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Commitment to Diversity and Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.
Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $107,200 and $160,800/annually at the Senior Scientist II level and $118,400 and $177,600 at the Principal Scientist I level however, while salary ranges are effective from 1/1/24 through 12/31/24, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
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The Novartis Group of Companies are Equal Opportunity Employers who are focused on building and advancing a culture of inclusion that values and celebrates individual differences, uniqueness, backgrounds and perspectives. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to fostering a diverse and inclusive workplace that reflects the world around us and connects us to the patients, customers and communities we serve.
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The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
